Chem. Pharm. Bull. 55(11) 1615—1619 (2007)

warded as a promising molecule because of its broad spectrum pharmacological activities like antitubercular, antibacterial, antifungal, anticancer, anti-HIV, anthelmintic, anti-inflammatory and antihypertensive activities. Imidazoles are one of the oldest and potent heterocyclic compounds having antimicrobial activities. Structure activity relationship studies of quinazolinone ring system revealed in various literatures suggest position 2, 6 and 8 are very much important for structure activity studies and position 3 should be attached to different heterocyclic rings for better chemotherapeutic activity. As these two heterocycles are present in biologically active compounds, we were interested in preparing compounds containing them. In view of these observations, we report herein the reactions of imidazoles with 2-chloro-N-(4-oxo-substituted-quinazolin-3(4H)-yl)-acetamides to give appropriate 2(1H-substituted-imidazol-1-yl)-N-(4-oxo-substituted-quinazolin-3(4H)-yl)-acetamides 8—11ad and their antimicrobial activities.